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There is a significant age-dependent increase in ferroptosis in the kidney, spleen, liver, ovary, uterus, cerebellum, and bone marrow, accompanied by iron accumulation 41

Beyond reducing cardiovascular risk, an ideal therapy for PAD should also improve symptoms while helping control cardiometabolic risk factors such as hyperglycemia, hypertension, and hyperlipidemia

Semaglutide, a weekly injection, has demonstrated superior efficacy in adult head-to-head trials and is becoming a preferred option when accessible

doi: 10.1016/j.gendis.2014.07.005 114 ZhangYTanHDanielsJDZandkarimiFLiuHBrownLMet al

Key Points for Patients It is a chronic condition: Crohns disease cannot currently be cured, but it can be managed effectively with the right treatment

While animal studies have suggested potential benefits, human safety and efficacy data are limited