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These effects are more likely at higher doses, particularly above 3,000 mg per day, and taking supplements with food can help reduce gastrointestinal discomfort

10.1038/s41538-023-00245-8 91 RauS.GreggA.YaceczkoS.LimketkaiB

That observation opened the door to investigating GLP-1 agonists for conditions driven primarily by inflammation rather than obesity