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Its dual-mechanism approach activating both the GLP-1 and GIP receptors can offer advantages in insulin sensitivity, fat metabolism, and sustained satiety that make it the better clinical fit for many patients

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For moderate weight loss with minimal side effects, a maintenance dose of 4mg provides 17% body weight reduction with a tolerable side effect profile

But that insulin release is glucose-dependent, meaning it ramps up when blood sugar is high and backs off when blood sugar is normal

What side effects should I expect when starting retatrutide