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I felt maybe slightly less hungry the first week, but that completely went away

May 2023

Safety profiles mirror brand-name equivalents when compounds are properly manufactured, stored, and administered

In addition, its weight loss effect may decay over time, and combination therapies need to be explored to maintain efficacy

Many patients describe feeling full sooner, needing smaller portions, or having quieter food noise persistent, intrusive thoughts about food reported by many patients with obesity

(For small-molecule drugs like semaglutide, at least seven years must have passed from its FDA approval date to be eligible for selection, and for drugs with multiple FDA approvals, CMS will use the earliest approval date to make this determination.) If that happens, a negotiated Medicare price would be available beginning in 2027