The honest answer is both
Aplicar una cantidad suficiente en la zona deseada
[1] [4] Regular follow-up appointments are essential for monitoring response, adjusting doses, and screening for potential complications throughout your treatment course
For most patients, the nausea is transient, typically occurring in the first 2 to 4 weeks or after a recent titration step, and symptoms often improve as the body recalibrates

Approval (2017) Novo Nordisk Press Release (18th October, 2025): FDA Approves Novo Nordisk's Oral Semaglutide For Cardiovascular (CV) Risk Reduction In Adults With Type 2 Diabetes Who Are At High Risk, Including Those Who Have Not Had A Prior CV Event Once-Weekly Semaglutide in Adults With Overweight or Obesity (March 2021) Efficacy And Safety Of Once-Weekly Semaglutide 20 Mg Versus 10 Mg In Patients With Type 2 Diabetes (SUSTAIN FORTE): A Double-Blind, Randomised, Phase 3b Trial (July 19, 2021) Oral Semaglutide Versus Subcutaneous Liraglutide And Placebo In Type 2 Diabetes (PIONEER 4): A Randomised, Double-Blind, Phase 3a Trial Novo Nordisk Press Release (21st October, 2024) Novo Nordisk A/S: Oral Semaglutide Demonstrates A 14% Reduction In Risk Of Major Adverse Cardiovascular Events In Adults With Type 2 Diabetes In The SOUL Trial Efficacy And Safety Of Once-Weekly Semaglutide 20 Mg Versus 10 Mg In Patients With Type 2 Diabetes (Sustain Forte): A Double-Blind, Randomised, Phase 3b Trial Metabolic Dysfunction-Associated Steatohepatitis And Progression To Hepatocellular Carcinoma: A Literature Review (March 20th, 2024)

Brain areas of interest (amygdala, dorsal and ventral hippocampus, PFC) were punched from slices (50m sections) using a cryostat (20C), and cytokine levels analyzed using electrochemiluminescence immunoassay kits