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Highly activated NRF2 target genes, encoding detoxification and antioxidant enzymes, confer a great advantage to cancer cells for survival against anti-cancer drugs and irradiation (Wang et al., 2008b

Moreover, in this work, Van Pelt and Truttmann mentioned an HSP70 member of the nematodes, F44E5.4 (initially cytosolic), to manage PQC in the ER in depletion of GRP78 orthologs, at least for the clearance of mutant polyglutamine proteins

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It ran for 72 weeks and tested three doses against placebo