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Activin type II receptor (ActRII) blockade is the most advanced mechanistic approach

For the DDD-Ube2e2-COP1-c-Jun-STK40 complex, the purified protein was prepared at a concentration of 0.52 mg/ml and mixed with 0.02% N-Octyl--D-glucopyranoside (OG) prior to cryo-EM grids preparation to mitigate the effects of preferred orientation of the particles

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