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When using dilute acetic acid (0.1% v/v) as a solvent, it can improve initial solubilization of certain peptide batches, but the solution pH should be adjusted to near-physiological range before administration to avoid tissue irritation at the injection site in animal models

doi:10.1016/S0014-5793(02)03040-5 Wegrowski Y, Maquart FX, Borel JP (1992) Stimulation of sulfated glycosaminoglycan synthesis by the tripeptidecopper complex glycyl-l-histidyl-l-lysine-Cu 2+

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