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SCFAs also regulate gene expression by inhibiting histone deacetylases (HDACs), maintain the Th17/Treg balance, and stimulate Staphylococcus epidermidis to produce antimicrobial peptides that limit colonization by Staphylococcus aureus [135]

LPS disrupts nitric oxide (NO) signaling, resulting in elevated levels of cyclic guanosine monophosphate (cGMP)