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Originally developed for type 2 diabetes, Tirzepatide has quickly become one of the most effective compounds for body recomposition and fat loss, outperforming even Semaglutide in clinical trials

Topical strength does not automatically transfer to injectable strength

Side effects may begin within the first few days to weeks after starting treatment

Tchkonia T et al

See retraction notice in J Pharmacol Exp Ther

While their mechanisms of action are similar, topical acetyl hexapeptide-8 does demonstrate a lower efficacy than injected Botox, but as researchers note this is to be expected.22 Similar results were found in a small 2013 study, with the total anti-wrinkle efficacy of the Argireline treatment group being 48.9% compared to 0% in the placebo group.23 However, a more recent 2023 study investigating the effects of serum containing Argireline and hyaluronic acid found the results to be not statistically significant.24 This means that more research is needed before claims that Argireline is a true alternative to Botox can be confirmed or denied