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CPM fvrier 2026 2026-03-26T07:53:26+01:00 2026-03-26T07:53:26+01:00 Patrick_Grard SSD s'est rendu sur place Mbujimayi Grce des des soutiens nombreux et diversifis et au dynamisme de son fondateur, le Dr Benot Mbyia, la Clinique Pdiatrique de Mbujimayi (CPM) en Rpublique Dmocratique du Congo, a connu ces dernires annes un dveloppement important au service de la population locale et, en particulier des enfants atteints de la drpanocytose, une maladie hrditaire du sang endmique dans cette partie du monde. Malgr ces avances importantes, il manquait encore une dimension essentielle : la possibilit de constater sur place les rsultats de ces efforts, de rencontrer les quipes locales et les patients

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Key pathophysiologic mechanisms include: Mucosal barrier dysfunction: Impaired epithelial tight junctions allow bacterial translocation, triggering innate immune activation T-helper cell dysregulation: Predominantly Th1 and Th17 pathways drive chronic inflammation via TNF-, IL-12, IL-23 the basis for biologic therapy targets Transmural inflammation: Unlike UC (mucosal only), CD involves all layers: mucosa submucosa muscularis propria serosa Granuloma formation: Non-caseating granulomas are pathognomonic but present in only ~3050% of biopsies Fibrosis and stricture: Chronic inflammation activates myofibroblasts collagen deposition luminal narrowing obstructive symptoms Fistula formation: Transmural ulcers penetrate serosa form sinus tracts connect to adjacent bowel, bladder, vagina, or skin 7

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