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Vuyyuri SB, Rinkinen J, Worden E, Shim H, Lee S, Davis KR

These effects are attributed to indirect modulation of signaling pathways involved in cell survival rather than direct stimulation of neuronal activity

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[27] The connection between GSTP inhibition of the pro-apoptotic JNK pathway and the isozyme's overexpression in drug-resistant tumor cells may itself account for the tumor cells' ability to escape apoptosis mediated by drugs that are not substrates of GSTP