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NAD + degradation NAD + consumption As a co-substrate important to various postsynthesis modifications of fundamental macromolecules, NAD + can be cleaved by NAD + -consuming enzymes including PARPs, sirtuins, CD38 and SARM1 to generate NAM and ADP-ribose (ADPR) (Fig

Decreased saliva production could make it harder to absorb vitamin B12 from the digestive tract

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Day 1: 100-200 mg NAD IV (1-3 hrs) Day 4: 50mg NAD SQ Day 6: 50mg NAD SQ Daily: 250mg NR/NMN in the morning Week 3 We also keep roughly the same routine, though you can ramp up to 500mg NAD IV at this point if you feel you can tolerate it's side effects during infusion