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It also resulted in a 13.2% decrease in body weight in an East Asian population with overweight or obesity, with or without T2DM

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However, the story is nuancedthe failure of the EVOKE trials testing oral Semaglutide in symptomatic Alzheimers Disease does not invalidate the strong epidemiological signal for GLP-1 agonists in dementia prevention, and SS-31s approval establishes important regulatory precedent for mitochondrial-targeted therapeutics

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