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NAC significantly reduced total testosterone (TT) levels (standardised mean difference (SMD): 025 ng/ml

Thus, EV-associated miRNAs in follicular fluid likely contribute to PCOS pathogenesis by altering granulosa cell functions, though their regulatory mechanisms require further exploration

More recently, Mn was found to increase LRRK2 expression, a protein associated with Parkinsons Disease, in vitro and in vivo , while LRRK2 deletion in microglia reduced cytokine release in vitro (Kim et al., 2019)

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