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This would be consistent with notions that somatostatin does not function as a circulating hormone, but mainly acts as a paracrine regulator acting locally on neighbouring cells in pancreatic islets and the intestine

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The resulting mutant models were solvated in a bounding box with a minimum of 2 nm padding distance, and Na + and Cl ions were added to neutralize the system up to an ionic strength of 0.15 M

Here, we found only low expression of Gipr across all neuronal types, while Glp-1r was more robustly expressed