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revealed that polarization-dependent fluorescence correlation spectroscopy (Pol-FCS) can be used for evaluation of macromolecular crowding and simultaneously measure the relaxation times of rotational and translational diffusion of fluorescent molecules at the same position, even in living cells (Yamamoto et al., 2021)

Most patients should receive metformin initially, but if control is suboptimal after 36 months, treatment intensification with another glucose-lowering therapy is required, and selection of subsequent therapies should be made on an individualized basis to meet the specific needs of the patient (4)

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