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However, SERM, AI, or prolactin inhibitor use during PCT remains an unproven practice (Bond et al., 2022)

Supplements are most effective when combined with rigorous pacing to prevent post-exertional malaise, careful symptom tracking to identify specific mast cell triggers, and the guidance of a medical team that truly understands complex chronic illness

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Dosing optimization requires experimentation within safe ranges - men typically need 1.5-2mg while women need 0.75-1mg, starting conservatively and adjusting based on response and side effect tolerance

[21] Moncayo R, Moncayo H

Both peptides bind the GHRH receptor (GHRH-R), a Gs protein-coupled receptor expressed on somatotroph cells of the anterior pituitary