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Enzymes work like small machines continuously processing while suitable substrate and conditions are available

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Respir Med 142:8693 De Carvalho FG, Galan BSM, Santos PC et al (2017) Taurine: a potential ergogenic aid for preventing muscle damage and protein catabolism and decreasing oxidative stress produced by endurance exercise

Higher body weight is independently associated with increased reflux risk because abdominal fat places additional pressure on the stomach