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Total cholesterol measurements included cholesteryl esters and free cholesterol, and cholesterol levels in cell lysates were normalized to protein concentration

Notably, NO exhibits dual rolesphysiological concentrations modulate cerebral blood flow via cyclic guanosine monophosphate (cGMP) pathways, whereas pathological levels inhibit cytochrome c oxidase, impair mitochondrial respiration, and induce glutamate excitotoxicity through NMDA receptor S-nitrosylation [52]

As a result, ubiquitination and degradation of DHODH were inhibited, and the mitochondrial ferroptosis pathway was subsequently blocked [85]

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Sugar-sweetened beverages account for nearly 60% of added sugar consumption in adults

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