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Many patients unconsciously increase portion sizes as appetite suppression eases, undoing the deficit that drove initial weight loss

Many employers are concerned that GLP-1s are being leveraged as first-line therapy for members newly diagnosed with diabetes and may want to ensure that metformin is being used first line when clinically appropriate

This is due to them being often bland, easily digestible, and they provide quick energy from the carbohydrates

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In 2015, researchers at Novo Nordisk published Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide 1