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International union of pharmacology

Molecular mechanisms and clinical manifestations of rare genetic disorders associated with type I collagen

In animal models, including db/db mice, streptozotocin (STZ)-induced diabetic models, and non-obese diabetic (NOD) mice, renal tissues show increased iron content, elevated levels of MDA and ACSL4 , and reduced GPX4 expression, which are the signature features of ferroptosis (Wang et al., 2020

It should also be noted that RBCs lack other NADPH-producing enzymes, and any loss of NADPH cannot be compensated by other pathways