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A possible explanation might be that constitutive RAS pathway activity promotes TFRC (a gene related to iron metabolism) expression while suppressing the expression of iron storage proteins

They do this by inhibiting the production of prostaglandins that protect the stomach wall from its own acid

dipeptidyl peptidase-4, an enzyme expressed on the surface of cells, terminates the blood glucose lowering action of GLP-1

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Studies have shown that HO-1 may be involved in the development of diabetic complications like diabetic kidney, diabetic cardiovascular disease, and diabetic wound healing