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La perdita di oltre il 60% del peptide circolante tra la seconda e la sesta decade di vita coincide con l'insorgenza dei segni clinici dell' invecchiamento cutaneo , della ridotta guarigione delle ferite e della degenerazione dei tessuti connettivi

Frontiers in Nutrition 10: 1099143

doi: 10.3390/ijms24044004 167 XiongJChenXZhaoZLiaoYZhouTXiangQJEet al

Ratiometric image analysis was conducted using a Python script (available from The background was subtracted for each channel and the ROIs (=transfected cells) were determined by thresholding or with the Cellpose 40 algorithm in the channel of the FP

This pathway involves the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2) by one of the four eIF2 kinases, reducing global protein synthesis and activating transcription factor ATF4 to restore homeostasis 145,146