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Specialized pro-resolving mediators (SPMs) are a class of PUFA-derived lipid mediators (49)

ATP signals to afferent nerve fibers via binding to P2X receptors but also feeds back in an autocrine fashion via binding to P2X and P2Y receptors on type II cells [36]

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Notable areas of expression include the brainstem, hypothalamus, hippocampus, and cortex ( 3.2 Semaglutides pharmacological profile and the blood-brain barrier Semaglutide is a GLP-1 analog with approximately 94% homology to human GLP-1

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