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People allergic to the drug should not use it Sodium Chloride Contraindications for Sodium Chloride Almost no issue at such small quantities used as dilution fluid, unless an allergic reaction occurs
The tradeoff is that the powder doesn't dissolve instantly
This escalation approach improves tolerability while identifying the minimum effective dose for each individual
Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates
It acts directly on several target tissues, including skeletal muscle and bone, but several effects are mediated indirectly by circulating (liver-derived) or locally produced IGF-1