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The identification of intracellular lipid remodeling as a determinant of ferroptosis resistance and the potential to reverse this phenotype using fibrates a widely prescribed drug class offers a promising avenue for translational investigation

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Given the central role of carnitine in fatty acid oxidation, 3 they examined whether SLC25A45 deficiency alters systemic fuel selection under basal conditions

Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP

Nonetheless, evidence for these findings is mainly limited to subjects in research or medically stable states