The iron addiction of tumor cells determines that the iron demand is more than that of healthy cells, which leads to cell death due to ferroptosis, mainly depending on the accumulation of iron ions, the metabolism of lipid peroxides and the regulation of related enzymes [33]
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The discovery of 5-FU up-regulation of GPX4 in this study is consistent with the latest reports, and the reproducibility of the results was further confirmed ( Here, we showed that GPX4 inhibition is a promising strategy to selectively eradicate residual CRC cell reservoirs
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