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View in: Pubmed Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

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J Nanobiotechnology

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Together with the binding of the T cell receptor to the HLAantigen complex, activation of the T cell immune response requires binding of co-stimulatory ligands such as B7 on antigen-presenting cells (APC) to the CD28 receptor on the T cell