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The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1

Nature 451 (7175), 141146

Therefore, caution should be exercised when extrapolating findings from cell and animal studies to human applications

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is a Professor Emerita, Departments of Physiology and Medicine at the University of Toronto, Toronto, ON, Canada

doi: 10.1016/j.biopha.2023.114465 28 SakashitaMTanakaTInagiR