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To investigate whether these DMF-mediated alterations are related to the expression changes of DNA methylation modifiers, we determined the expression of DNA methyltransferases (DNMTs) and TET methylcytosine dioxygenases (TETs) in cultured Day 12 SCD erythroblasts

This is evidenced by the inhibition of their growth in immunodeficient mice following lentivirus-mediated GCLC silencing