(Cambridge, Mass.) 20 , 138146
The only exception is vitamin B12, which can be stored in the liver
Recent studies with animal models provide evidence that pheomelanin pigment pathway is implicated in UV radiation-independent carcinogenic contributions to melanomagenesis by mechanisms of oxidative damage 6,7,8 Two non-exclusive hypotheses were proposed to define pheomelanins pro-oxidant activity: (i) the pigment promotes the formation of damaging ROS and (ii) the pigment depletes protective antioxidants (e.g., glutathione) 9,10
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