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Treatment must be combined with reduced-calorie diet and increased physical activity, and is contraindicated in pregnancy and personal or family history of medullary thyroid carcinoma

Retatrutide is the lead candidate in this category, but is still in clinical trials

Less frequent effects include fatigue or reduced appetite

This information should be interpreted with a qualified healthcare provider to inform personalized dosing strategies during illness

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Experiments were performed in triplicate with three independent repeats