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10.1016/j.krcp.2015.08.004 Kidney Res Clin Pract

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Evidence for alterations in tissue carnitine transport

After helping patients organize their treatment routines, the pattern became clear: confusion breeds stop-start adherence, and stop-start adherence magnifies the drug's apparent cost because results slow and refills feel wasteful

Impaired pulmonary function as a risk factor for mortality

In addition, a 13% and 16% decrease in Cmax,ss and AUC,ss respectively, of the active hydroxy-metabolite was noted as well as a 60% decrease in Cmax,ss and AUC,ss of the active keto-metabolite [see Drug Interactions (7)]