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This activation ameliorates the imbalance in mitochondrial dynamics by modulating the expression of MFN2 and DRP1, ultimately improving renal tubular ATP production (114)

In some embodiments, high viscosity formulations or devices contain from about 14% to about 22% of a viscosity enhancing agent or viscosity modulating agent (e.g., gelling components such as polyoxyethylene-polyoxypropylene copolymers)