This review examines the main effects of GLP-1 and its analogs, GLP-1RA, on the body, with a focus on the brain mechanisms mediated by the GLP-1R, which form the basis for using these compounds to treat brain diseases and comorbidities
Many patients stay on a plan for 36 months, followed by ongoing review
57,186 Alterations in gut microbiota composition, compromised intestinal barrier integrity, and abnormal translocation of microbial metabolites allow endotoxins, such as LPS, to reach the liver via the portal circulation
Among pharmacologic options, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained particular interest over recent years (33, 34)
Side-effect management guided by health care providers with expertise in managing patients with obesity is also key
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