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Vitamin B12 is stored in the liver, so if you stop consuming foods that contain this vitaminfor example, if you adopt a vegan or vegetarian lifestyleit can actually take between 3 and 5 years before the body uses up its supply of vitamin B12

(PubMed) Yoshihisa A, Watanabe S, Yokokawa T, et al

Among these elements, ATF3 predominantly regulates the basal and stress-induced expression of ChaC1 through ATF/CRE, while ATF4 primarily regulates stress-induced ChaC1 expression through ATF/CRE and ACM (48)

Week 9 and beyond: Reach the target maintenance dose, which is personalized depending on treatment goals and patient response

Neuropharmacology 55 , 10721080 (2008)