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Results: Effect size for desire: 0.49 to 0.61 Effect size for distress reduction: 0.60 to 0.62 25% of treated patients versus 17% placebo achieved clinically meaningful desire increase 35% versus 31% achieved clinically meaningful distress reduction A 52-week open-label extension confirmed sustained efficacy and safety (PMC6819021, PMC6819023)
Digestive benefits like reduced bloating and improved regularity also receive frequent praise
Lee KK, Imaizumi N, Chamberland SR, Alder NN, Boelsterli UA (2015) Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury
Consistency: The solution should flow freely when you tilt the vial
Heart Health (MACE) JAMA Netw Open
doi: 10.1016/j.mce.2014.10.025 74 PerryRCraigSLNgMTGaultVAFlattPRIrwinN
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