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This condition occurs approximately in about 5% of the population, however, among patients with cardiovascular diseases this condition occurs in up to 45% of patients and represents a serious risk of heart attack, endothelial dysfunction, arterial diseases, extracranial carotid artery disease, a common cause of the transient ischemic attack, termed also mini-stroke

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Acknowledgements This work was supported by the Austrian Science Fund (10.55776/COE16, T.H.), the Swedish Research Council (2023-03058, T.H.), the Swedish Brain Foundation (FO2022-0300, T.H.), the Novo Nordisk Foundation (NNF23OC0084476, T.H.) and the European Research Council (ERC-2020-AdG-101021016

Secondary antibodies were removed with 2 quick PBS washes and 48 min washes in PBS with agitation

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