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The half-life of GLP-1 is short

Respiratory Indications: As a topical nasal spray (0.25% to 1% solution), it reduces nasal mucosal congestion through localized vasoconstriction

Rescue therapy was needed by 8%, 25%, and 67%, respectively. Five milligrams preserved most, but not all, of the benefit of continuing the effective dose

Milk Thistle Both compounds address oxidative stress and hepatic metabolism through distinct mechanisms

PMID 22036099