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Most are injected subcutaneously (under the skin) once daily or weekly using a simple pen device

First-time prescribing of AOMs also decreased in September 2025, relative to June 2025 (-9.5%)

The primary ones involve worsened side effects like nausea and a risk of hypoglycemia (low blood glucose levels), especially for those with diabetes

161 The results of the Phase II clinical trials of retatrutide were published in The Lancet in 2023

Weight loss results with Ozempic can vary

As a novel GLP-1 receptor agonist, Retatrutide stands out by also targeting another third receptor to potentially amplify its impact on both weight reduction and blood sugar management