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This was confirmed in one MS mouse model, which showed that DMF-mediated protection against acute inflammatory autoimmune encephalomyelitis was observed in both NRF2-proficient and NRF2-deficient animals (Schulze-Topphoff et al., 2016) and likewise, SFN has been demonstrated to have hundreds of molecular targets next to KEAP1 (Li et al., 2020)

Figure 6 Each bar represents the mean SEM, Effect of silymarin on time spent in the open-arm (upper panel) and closed arm (lower panel) of the elevated plus maze