VRK2 facilitates ER-to-Golgi transport of SLC7A11 by promoting the phosphorylation of Sec24C and its interaction with SLC7A11, thereby enhancing GSH synthesis and rendering resistance to ferroptosis
MOTS-c is a peptide derived from mitochondria, encoded by the mitochondrial genome, and is studied for its role in cellular energy regulation and metabolic signaling
Clinically, plasma levels of these species are 2-3-fold higher in DKD patients than in those with diabetes alone and correlate positively with the urinary albumin-to-creatinine ratio [47, 48]
Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, et al
Moreover, macrophage-driven foam cell formation might be increased by the interaction between homocysteine thiolactone and LDL (McCully, 1996
Peptide bonds of AspGly and AspPro are most susceptible to hydrolytic protein cleavage (75,76)