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The authors claim that it is the most comprehensive collection of evidence on post-GLP-1RA weight outcomes to date. Weight regain after GLP-1 discontinuation The study searched multiple databases for randomized controlled trials (RCTs), non-randomized interventional studies, and observational studies examining weight trajectories after discontinuing GLP-1RAs

PMCID: PMC5188422

The leading hypothesis points to the glucagon component, but high-dose Wegovy has now shown similar effects