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Genet Med 2012;14:10-26

Engaging both the GIP and GLP-1 systems is what distinguishes the dual-agonist class from single-receptor agonists, and it is the reason the compound is studied as its own category

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However, even in the absence of fatty acids, GSIS was enhanced in lipofermata-treated islets, suggesting that FATP2 inhibition may mediate insulinotropic effects independent of fatty acid uptake