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The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

We also identified several further observational investigations

We can't find any human trials showing this probiotic to have a significant anti-obesity effect, nor can we find any human trials testing the specific strain used by Pendulum ( Akkermansia muciniphila WB-STR-0001) on obesity levels in humans

Importantly, although their glucose-lowering efficacy diminishes in advanced CKD, cardiovascular and kidney benefits remain preserved [111]

The trial is "double-blind," which means neither you nor your doctor knows whether you got the real drug or the placebo until the trial is over