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Semax, Noopept and several other compounds are reported as increasing hippocampal BDNF

Cancer Epidemiol Biomarkers Prev (2011) 20(5):799810

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Relation to Neuroprotection: Such synthetic substances bind to GLP-1 receptors in the cortex, hippocampus, amygdala, and basal ganglia, triggering the following signal transduction: Switching off inflammatory NF-B downstream pathways like cytokines (IL-1/IL-6) and tumor necrosis factor (TNF-)

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NAD is generally considered safe in healthy invidivuals