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It is likely that the recovery of MafA expression after such treatment is particularly important for the recovery of the -cell function and amelioration of glycemic control, because MafA regulates not only insulin but also various factors related to GSIS

COMBINE 3 enrolled 679 patients inadequately controlled on basal insulin therapy and evaluated non-inferiority against a combination regimen of insulin glargine 100 U/mL and insulin aspart

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Several authors have demonstrated the effects of metformin on the metabolic syndrome [31, 32]