high pharmacologic doses (1-3 g/day) can cause hypotension, insulin resistance, and hepatotoxicity
General guidelines suggest individuals under 150 pounds may start with 50-75mg daily, those between 150 and 200 pounds typically use 75mg daily as a standard protocol, and individuals over 200 pounds may need 75-100mg daily for optimal effects
High doses may put additional strain on the kidneys, potentially causing adverse effects
You might need to change your dose if your symptoms dont get better or if lab results show youre not getting enough B12
Folate alone can improve blood findings while B12-related nerve injury continues, so diagnosis and follow-up are important before changing products or adding supplements
3f), and its relative abundance was lowest in WD control mice compared to all other groups