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SURPASS-2: The Only Head-to-Head Trial The SURPASS-2 trial (NEJM, 2021) is the most important study in this comparison because it directly tested tirzepatide against semaglutide in 1,879 patients with type 2 diabetes over 40 weeks

Common side effects may include: Addressing these risks with professional guidance helps ensure a safer experience when using peptides for bodybuilding

Results are based on self-reported data from Josie members on personalized treatment plans, including compounded GLP-1 medications and provider consultations

In clinical trials, people who stopped semaglutide often regained much of the weight they had lost

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Some providers prefer to start patients on oral semaglutide to establish tolerability before escalating to injectable tirzepatide